National and International Guidelines

2025 Very High Risk breast screening form

On 30th April 2025 on the new Very High Risk Breast Screening form from the National Breast Screening Programme (NHSBP) went live. There was a virtual meeting hosted on the same day.

Please find links to the following

Webinar recording (Dropbox link)

Webinar recording (Googledrive link)

Link to the new VHRS Form which went live 29/04/2025 – please note referrals on the previous form will not be accepted beyond 18 May 2025

NICE guidance on familial breast cancer

The 2013 NICE guidelines for familial breast cancer are available here.

NICE Quality Standard for Ovarian cancer

The NICE Quality Standard for Ovarian cancer can be found at  https://www.nice.org.uk/guidance/qs18

Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG

UKCGG has worked with the British Society of Gastroenterology and the Association of Coloproctologists of Great Britain and Ireland to produce 2019 guidance on the screening and management of patients with an increased genetic predisposition to colorectal cancer. 

 

Unfortunately there is not enough evidence regarding the use of aspirin in patients at high/moderate risk of colorectal cancer outside of the context of Lynch Syndrome. Low dose aspirin has been shown to be effective in reducing cancer risk in Lynch Syndrome and the general population. Low dose aspirin has been shown to reduce risk of recurrence in those who have had bowel cancer. Whilst we cannot recommend low dose (75mg) aspirin to patients at high/moderate risk based on family history due to lack of studies in this group of patients, it seems likely that future studies will show effectiveness of daily low dose aspirin in this cohort as well with similar paradigms to Lynch and population based studies. We want to advocate for these studies to be undertaken to confirm this.

 

European Guidelines for Lynch Syndrome

The 2013 European Guidelines for Lynch Syndrome management have been superseded by the recently published UK gene-specific guidelines.  The full original text for the 2013 guidelines produced by the Mallorca group can be accessed here.

National and International Guidelines

Peer-reviewed published guidelines from national and international expert groups are available at the links here below. For additional UKCGG guidelines and leaflets, please click here. 

Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer

The 2013 NICE guidelines for familial breast cancer are available here.

Breast Cancer Chemoprevention

CGG have produced information leaflets that may be used for women at increased risk of breast cancer who are considering the use of chemoprevention.

The leaflets are available from here. Please note that any use of the leaflets is the responsibility of the health professional/person concerned.

Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG

UKCGG has worked with the British Society of Gastroenterology and the Association of Coloproctologists of Great Britain and Ireland to produce new guidance on the screening and management of patients with an increased genetic predisposition to colorectal cancer. 

Unfortunately there is not enough evidence to review regarding the use of aspirin in patients at high risk of colorectal cancer outside of the context of Lynch Syndrome. However, given the evidence supporting use of aspirin in Lynch Syndrome and the growing body of evidence with respect to reduction in colorectal cancer risk with aspirin in the general population, we advise that patients at high risk of developing colorectal cancer on the basis of their family history should see their GP to discuss the risks and benefits of low dose (75-150mg) daily aspirin for bowel cancer risk reduction. 

2013 Mallorca Group paper : European guidance on Lynch syndrome

The 2013 European Guidelines for Lynch Syndrome management have been superseded by the recently published UK gene specific guidelines.  The full original full text for the 2013 guidelines produced by the Mallorca group can be accessed here.

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