National and International Guidelines

NICE guidance on familial breast cancer

Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer

The 2013 NICE guidelines for familial breast cancer are available here.

Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)

Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG

UKCGG has worked with the British Society of Gastroenterology and the Association of Coloproctologists of Great Britain and Ireland to produce new guidance on the screening and management of patients with an increased genetic predisposition to colorectal cancer.

Unfortunately there is not enough evidence to review regarding the use of aspirin in patients at high risk of colorectal cancer outside of the context of Lynch Syndrome. However, given the evidence supporting use of aspirin in Lynch Syndrome and the growing body of evidence with respect to reduction in colorectal cancer risk with aspirin in the general population, we advise that patients at high risk of developing colorectal cancer on the basis of their family history should see their GP to discuss the risks and benefits of low dose (75-150mg) daily aspirin for bowel cancer risk reduction.

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/ United Kingdom Cancer Genetics Group (UKCGG)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

Implementing Lynch Syndrome testing and surveillance pathways: a guide for cancer alliances

Implementing Lynch Syndrome testing and surveillance pathways - a guide for cancer alliances - slides

Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene‑CanVar Clinical Guideline Working Group

Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene‑CanVar Clinical Guideline Working Group

UKCGG consensus group guidelines for the management of patients with constitutional TP53 pathogenic variants

UKCGG consensus group guidelines for the management of patients with constitutional TP53 pathogenic variants