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The InSiGHT group have recently published a consensus statement regarding management of carriers of the APC risk allele p.I1307K. However, many of the recommendations could not be implemented in the NHS/UK context, for which reason we have written a UK-specific position statement. Please find relevant documents here below.
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Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K and cancer risk
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UKCGG Position Statement (in response to InSiGHT): Challenges in developing and implementing international best practice guidance for intermediate-risk variants in cancer susceptibility genes: APC c.3920T>A p.(Ile1307Lys) as an exemplar
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